LMPTP INHIBITOR 1 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LMPTP INHIBITOR 1 diHClide 是低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂，IC50 为 0.8 μM LMPTP-A。

LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an?IC50?of 0.8 μM LMPTP-A.(In Vitro):LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50?of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.(In Vivo):LMPTP inhibitor 1 dihydrochloride is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 dihydrochloride (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.

LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.

LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.

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Metabolic Enzyme/Protease

Phosphatase

E3 Ligase Ligand-Linker Conjugate

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2310135-46-5

517.54

C28H38Cl2N4O

>98% (HPLC)

In Vitro:?DMSO : ≥ 64 mg/mL (123.66 mM)

Cl.Cl.CCN(CC)C(=O)c1ccc(cc1)-c1cc(NCCCN2CCCCC2)c2ccccc2n1

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(-20℃)

With Ice Pack

≥ 2 years